Detailed Product Description
INTRODUCTION:
ACE-031 is a soluble form of activin receptor type IIB (ActRIIB). ACE-031 promotes muscle growth by binding to myostatin and other negative regulators of muscle mass.
METHODS:
This double-blind, placebo-controlled study evaluated the safety, pharmacokinetics, and pharmacodynamics of ACE-031 in 48 healthy, postmenopausal women randomized to receive 1 dose of ACE-031 (0.02-3 mg/kg s.c.) or placebo (3:1).
RESULTS:
ACE-031 was generally well-tolerated. Adverse events included injection site erythema. Mean ACE-031 AUC(0-∞) and C(max) increased linearly with dose; mean T(½) was 10-15 days. Statistically significant increases in mean total body lean mass (3.3%; P = 0.03, by DXA) and thigh muscle volume (5.1%; P = 0.03, by MRI) were observed at day 29 in the 3 mg/kg group. Statistically significant changes in serum biomarkers suggest ACE-031 also improved bone and fat metabolism.
CONCLUSIONS:
Single-dose ACE-031 treatment was generally well-tolerated and resulted in increases in muscle mass in healthy postmenopausal women.
Delivery and shipping:
1. We will ship the goods within 2 days after payment.
2. We will ship the goods by UPS,EMS,DHL, TNT or FEDEX . We will choose the best courier depend on Different countries, and find the safe way to deliver the goods for you.
3. Like Russia, Australia, Canada, customs is very strict, but we can ensure 100% delivery.
4. As usual you can get the goods with in 4-7days. If the goods were lost or not received for other reasons, we'll resend.
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